ANTI-PSYCHOTICS.docx - LECTURE 6 DRUGS USED IN PSYCHOSIS Psychoses These are severe psychiatric illness with serious distortion of thought behavior

ANTI-PSYCHOTICS.docx - LECTURE 6 DRUGS USED IN PSYCHOSIS...

This preview shows page 1 - 3 out of 9 pages.

LECTURE 6 DRUGS USED IN PSYCHOSIS Psychoses: These are severe psychiatric illness with serious distortion of thought, behavior, capacity to recognize reality and of perception. Patient is unable to meet ordinary demands of life ANTI-PSYCHOTIC DRUGS CLASSIFICATION 1) Phenothiazenes Aliphatic side chain: Chlorpromazine, Influpromazine Piperidine side chain: Thioridazine Piperazine side chain: Trifluoperazine, Fluphenazire 2) Butyrophenones : Haloperidol , Trifluperidol , perifluridol 3) Thioxanthenes : Flupenthixol 4) Other heterocyclics : Loxapine 5) Atypical Antipsychotics: Risperidone, Olanzapine , Ziprasidone Pharmacological Actions Pharmacology of Chlorpromazine (CPZ) is described as the prototype others as they only differs from it. a. Central Nervous System In a psychotic, CPZ reduces irrational behavior, agitation , aggressiveness, Disturbed thought is normalized gradually, anxiety is relieved. Hyperactivity, hallucinations, delusions are suppressed. All phenothiezine, thioxanthenes, butyrophenones have similar anti-psychotic efficacy but potency differs in equipotent dose. Mechanism Of Action All anti-psychotics (except Clozapinine-like atypical) have potent dopamine D 2 receptor blocking action Also block D1, D3,D4 receptor, bud there is correlation with anti-psychotic potency. Blockade of dopaminerigic projections to the temporal and prefrontal areas constituting the limbic system and in mesocortical areas is responsible for antipsychotic action b. Autonomic Nervous System :-Neuroleptics have varying degrees of alpha adrenergic blocking activity may be. Anti-cholinergic properties are weak. c. Cardiovascular System:- Produce postural hypotension, high dose of CPZ directly depress the heart of and produce ECG changers (Q-T prolongation and suppression of T- wave) d. Local Anaesthetic:- CPZ is a potent local anesthetic. However not used for this action because of its irritation action.
Image of page 1
e. Endocrine:- Neuroleptics consistently increase prolactin release by blocking the inhibitory action of Dopamine on pituitary lactotropes. This may result into galactorrhoea, and gynaecomastia. Decrease in ADH may result in increase urine volume.
Image of page 2
Image of page 3

You've reached the end of your free preview.

Want to read all 9 pages?

  • Fall '19

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes
A+ icon
Ask Expert Tutors