LEPROSY.ppt - LEPROSY Joseph Kibirige(B.Pharm MPS LEPROSY… • Leprosy is a chronic Infectious Disease caused by Mycobacterium leprae-Acid fast

LEPROSY.ppt - LEPROSY Joseph Kibirige(B.Pharm MPS...

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LEPROSY Joseph Kibirige (B.Pharm, MPS)
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LEPROSY… Leprosy is a chronic Infectious Disease caused by Mycobacterium leprae- Acid fast bacilli It affects the skin, peripheral nerves and mucous membranes (eyes, respiratory tract).
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LEPROSY… It is also known as Hansen's disease as bacillus causing it was discovered by G.A. Hansen in 1873. It is common in warm, wet areas in the tropics & subtropics. It is transmitted from one person to another via the respiratory tract or skin.
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INTRODUCTION Mycobacterium are very slow growing organisms. Mycobacterium can also be dormant Most antibiotics are effective against rapidly growing organisms Mycobacterium also have a lipid rich cell wall which is impermeable to many drugs. Yet mycobacterium tend to be intracellular
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Mycobacteria are also notorious for developing resistance to single drugs Response to Rx is slow and must go on for months Combination of drugs are required to overcome the above obstacles.
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CLASSIFICATION OF LEPROSY INFECTIONS Why? 1)Tuberculoid or Paucibacillary (PB) leprosy Have up to 5 skin (1-5)lesions in total.
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