Lecture 11 - Cardiac Cycle (Fall2019).pptx - How does the hydrolysis of ATP(to ADP P alter proteins in a muscle cell to allow for contraction A

Lecture 11 - Cardiac Cycle (Fall2019).pptx - How does the...

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How does the hydrolysis of ATP (to ADP+P) alter proteins in a muscle cell to allow for contraction? A) Hydrolysis results in activation of myosin to the extended “ready” position. B) Hydrolysis results in activation of myosin to the flexed “bent” position. C) Hydrolysis results in the movement of tropomyosin so that actin active sites are revealed. D) Hydrolysis results in the breakage of cross bridges between actin and myosin.
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Fact or Fiction? Truth or Tale? Heart failure = heart stops beating (A)True (B)False
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Thursday, October 3rd Today: Quiz 6 opens tonight 8 pm, due Sunday 11:59 pm Heart Anatomy, The Cardiac Cycle, Blood Vessels Next Week: Complete Blood Pressure control packet Complete Blood Pressure Reflex Wkst Lecture 12 -Vessel Function and Blood Pressure See Review Packets Youtube Video Playlist: ? list=PLYOAD6_xpxBS5RK1e64GhfpTAVO-NHUNs Tuesday, October 15 th – EXAM II (010 Sparks) NO CLASS TUESDAY – OCT. 8 th !!!!!!!!
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Cardiac Hypertrophy Enlargement, thickening of the cardiac muscle tissue Could be due to amount of exercise, hypertension, or valvular disease
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Cardiac Conduction System ? v=RYZ4daFwMa8 How the Heart Works ? v=oHMmtqKgs50
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Heart II Cardiac Conduction and Contraction
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How does the Heart Work? The heart is a ‘functional syncytium’ Contraction occurs in stereotypical pattern First atria contract (both at the same time!) Then ventricles contract (both at the same time!) Cardiac conduction system coordinates contraction Specialized conduction cells direct action potentials Contractile cardiac muscle cells (myocardium) then shorten together See hand drawn depolarization notes Ca+ and Na+
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Cardiac Conduction System Network of specialized cardiac muscle cells Allows cardiac tissue to be autorhythmic Produce and distribute action potentials Consists of Sinoatrial (SA) node (pacemaker) Atrioventricular (AV) node Conducting cells AV bundle (bundle of His) Bundle branches Purkinje (subendocardial) fibers
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Timing! Delay must exist between excitation and cardiac contraction Internodal pathways direct and slow action potentials Atria must contract first Ventricles must contract 2 nd from apex to base Moderator band directs AP to To papillary muscles Tension on AV valves blood moves out through SL valves to great vessels at base
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SA and AV nodes Pacemaker Potential Node cell membranes do not have a stable resting potential Following repolarization membrane drifts toward threshold. Rate of depolarization = heart rate SA node depolarizes at a rate of 80-100 b/m AV node 40-60 b/m What is a normal heart rate?
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