Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 10: Antiviral AgentsChapter 10: Antiviral Agents
Copyright © 2017 Wolters Kluwer • All Rights ReservedViruses That Respond to Antiviral TherapyViruses That Respond to Antiviral Therapy•Influenza A and some respiratory viruses•Herpes viruses•Cytomegalovirus (CMV)•Human immunodeficiency virus (HIV) that causes acquired-immune deficiency syndrome (AIDS)•Hepatitis B and C•Some viruses that cause warts and certain eye infections
Copyright © 2017 Wolters Kluwer • All Rights ReservedCharacteristics of Common VirusesCharacteristics of Common Viruses•A virus cannot replicate on its own•It must attach to and enter a host cell•It then uses the host cell’s energy to synthesize protein, DNA, and RNA.•Viruses are difficult to kill because they live inside our cells•Any drug that kills a virus may also kill our cells
Copyright © 2017 Wolters Kluwer • All Rights ReservedStages of Virus ReplicationStages of Virus Replication
Copyright © 2017 Wolters Kluwer • All Rights ReservedCharacteristics of Antiviral DrugsCharacteristics of Antiviral Drugs•Able to enter the cells infected with virus•Interfere with viral nucleic acid synthesis and/or regulation•Some agents interfere with ability of virus to bind to cells•Some agents stimulate the body's immune system•KNOW: Acyclovir (Zovirax) and Zidovudine (AZT)•**Note most antiviral –VIR endings**
Copyright © 2017 Wolters Kluwer • All Rights ReservedCommon Respiratory VirusesCommon Respiratory Viruses•Influenza A•Influenza B•Respiratory Syncytial Virus (RSV)
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