Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 51: Diuretic AgentsChapter 51: Diuretic Agents
Copyright © 2017 Wolters Kluwer • All Rights ReservedClasses of DiureticsClasses of Diuretics•Thiazide and Thiazide-like Diuretics•Loop Diuretics•Carbonic Anhydrase Inhibitors•Potassium-Sparing Diuretics•Osmotic Diuretics
Copyright © 2017 Wolters Kluwer • All Rights ReservedFunction of Diuretic AgentsFunction of Diuretic Agents•Increase the amount of urine produced by the kidneys•Increase sodium excretion
Copyright © 2017 Wolters Kluwer • All Rights ReservedIndications for Diuretic UseIndications for Diuretic Use•Edema associated with congestive heart failure•Acute pulmonary edema•Liver disease (including cirrhosis)•Renal disease•Hypertension•Conditions that cause hyperkalemia
Copyright © 2017 Wolters Kluwer • All Rights ReservedSites of Action of Diuretics Sites of Action of Diuretics
Copyright © 2017 Wolters Kluwer • All Rights ReservedUse of Diuretic Agents Across the LifespanUse of Diuretic Agents Across the Lifespan
Copyright © 2017 Wolters Kluwer • All Rights ReservedThiazide and Thiazide-Like DiureticsThiazide and Thiazide-Like Diuretics•KNOW: Hydrochlorothiazide (HydroDIURIL, HCTZ) •Chlorothiazide (Diuril)•Bendroflumethiazide (Naturetin)•Benzthiazide (Exna)•Hydroflumethiazide (Diucardin)•Methyclothiazide (Aquatensen)•Polythiazide (Renese)•Trichlormethiazide (Diurese) •**Note –THIAZIDE endings**
Copyright © 2017 Wolters Kluwer • All Rights ReservedThiazide and Thiazide-Like Diuretics (cont.)Thiazide and Thiazide-Like Diuretics (cont.)•Actions–Action is to block the chloride pump–Keeps chloride and the sodium in the tubule to be excreted in the urine, thus preventing the reabsorption of both in the vascular system•
