MCDB 428 Exam II Key Winter 2008

MCDB 428 Exam II Key Winter 2008 - Name _ Your GSI_ MCDB...

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Name ____________________________________ Your GSI_________________ MCDB 428 Cell Biology February 21, 2008 Exam II The exam has 11 questions from lectures 10-18 (the whole exam is 100 pts) Remember to pace yourself; the exam time is 2 hours For the short answer questions, you can continue on the back of the page if necessary Please write your name on the top right hand corner of each page The exam proctors will not answer questions during the test unless they concern typos, or unless essential information is missing Points will be deducted if what you write is incorrect whether or not it is relevant Good Luck! Question 1 (12 pts) _________ Question 2 (6 pts) _________ Question 3 (12 pts) _________ Question 4 (8 pts) _________ Question 5 (8 pts) _________ Question 6 (12 pts) _________ Question 7 (12 pts) _________ Question 8 (8 pts) _________ Question 9 (8 pts) _________ Question 10 (8 pts) _________ Question 11 (6 pts) _________ Your score ____________( out of 100) 1
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Name ____________________________________ 1. (12pts) Match the following terms with their definitions: Adaptor protein COPII-coated vesicle retromer Arf GTPase dynamin Sar1 GTPase C l a t h r i n N S F S N A R E Clathrin-coated vesicle phosphatidylinositide transport vesicle Coated vesicle Rab effector t-SNARE Coat-recruitment GTPase Rab GTPase v-SNARE COPI-coated vesicle a) General term for a membrane-enclosed container that moves material between membrane- enclosed compartments within the cell. Transport vesicle b) Any of a large family of monomeric GTPases present in the plasma membrane and organellar membranes that confer specificity with vesicle docking. Rab GTPase c) A protein that mediates binding between the clathrin coat and transmembrane proteins, including transmembrane cargo receptors. Adaptor protein d) Cytosolic GTPase that binds the neck of a clathrin-coated vesicle and helps it pinch off from the membrane. Dynamin e) The protein that catalyzes the disassembly of the helical domains of cis-paired SNARE complexes. NSF f) Coated vesicle that transports material from the plasma membrane, and between endosomal and Golgi compartments. Clathrin-coated vesicle g) The coat-recruitment GTPase responsible for both COPI coat assembly and clathrin coat assembly at Golgi membranes. Arf GTPase 2
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Name ____________________________________ h) Protein that facilitates vesicle transport, docking, and membrane fusion once it is bound by an active Rab GTPase protein. Rab effector i) General term for a member of the large family of proteins that catalyze the membrane fusion reactions in membrane transport. SNARE j) A multiprotein complex that assembles on endosomal membranes only when it can bind the cytoplasmic tail of a receptor in a curved membrane that is enriched for phosphatidylinositol 3- phosphate (PI-3P). Retromer
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MCDB 428 Exam II Key Winter 2008 - Name _ Your GSI_ MCDB...

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