Palmiter_lecture.ppt - Neurobiology of drug action and addiction Richard Palmiter Dept Biochemistry The dopamine reward system Prefrontal cortex

Palmiter_lecture.ppt - Neurobiology of drug action and...

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Neurobiology of drug action and addiction Richard Palmiter Dept Biochemistry
Substantia nigra Ventral tegmental area Nucleus accumbens Prefrontal cortex Hippocampus The dopamine reward system Wise (2002) Neuron Striatum
Some dopamine circuit details D1R D2R DA GABA GABA A R GABA A R NAc VTA
Drugs release dopamine D1R D2R DA NAc VTA DA Cocaine, amphetamine Morphine, heroin, nicotine Ethanol ?
Animals like drugs that release dopamine self administration
Animals like dopamine self stimulation Glu
Dopamine help animals learn where important (salient) things happen
Animals like the effects of drugs drug Conditioned place preference Animals learn to like the place where they experience the effects of drugs
Drugs usurp to dopamine system Drugs have greatest effect when given in a novel environment
Voluntary drug administration Involuntary drug administration ‘yoked situation’ Voluntary drug administration is more addictive than involuntary administration
Chronic drug exposure changes the brain
Imagining the brain on drugs Volkow (2004) Nat Rev. Is reduced D2R availability due to less receptor or more DA?
Robinson, TE (2004) Distal spines Medium spiny neuron morphology in NAc changes amphetamine

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