Lect_5_notes - Bio 1A Lecture 5 Biological Membranes...

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Bio 1A Lecture 5 February 1, 2008 Professor Schlissel Biological Membranes 1. Why do cells have membranes and what do they do? Localization of molecules and functions; control intracellular composition. Receiving and sending information. Interacting with other cells. Shape changes and movement. 2. Overview of membrane bound compartments within cells: nucleus, golgi, endoplasmic reticulum (ER), lysosome, peroxisome, mitochondrion, vesicles. 3. General structure of membrane. ~7nm lipid bilayer. Embedded proteins; cholesterol; modified lipids 4. How do proteins interact with membranes? Peripheral or integral (transmembrane). Type I- N-terminal faces out. Type II- C-terminal faces out. Lipid linked. Type III – multi-pass. Hydrophobicity plot allows for predictions of transmembrane domains. Fatty acid or glycolipid-modified proteins. Carbohydrate groups; disulfide bonds. 5. Fluidity of membranes. Diffusion within membrane. Effects of unsaturated fatty acids, temperature, cholesterol. 6. How to study membrane proteins. Disrupt cells with detergents. Analyze by gel
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