Lect_6_notes - Bio 1A Lecture 6 February 4 2008 Professor...

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Bio 1A Lecture 6 February 4, 2008 Professor Schlissel Cells and Organelles I 1. Limits to cell size based on surface area to volume ratio. 2. Prokaryotic cells. Nucleoid, ribosomes, cell wall, capsule, plasma membrane. No membrane-bound organelles; no nucleus; usually a circular chromosome; plasmids. 2a. Plant cells vs. animal cells—unique features of each. 3. Organelles: specialized, membrane delimited structures within cells. Used to create distinct chemical environments (pH, macromolecules, substrates), impose order on events (secretory pathway). 4. Techniques: Differential centrifugation; light and electron microscopy; freeze- fracture. 5. The nucleus. Contains genetic information; chromatin, chromosomes; nucleoli (sites of ribosome biogenesis); double layer membrane called nuclear envelope contiguous with ER; nuclear pores and regulated transport. 6. Endoplasmic reticulum (EF). Continuous with nuclear envelope. Smooth—synthesis of lipids, CHO metabolism, detoxification of drugs. Rough ER—site of membrane bound or secreted protein synthesis; rough due to presence of ribosomes on outer surface.
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