Lect_7_notes - Bio 1A Lecture 7 February 6 2008 Professor...

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Bio 1A Lecture 7 February 6, 2008 Professor Schlissel Cells and Organelles II 1. Vesicular transport. How proteins travel from the RER and cell membrane to other locations in cells. Budding and fusion. Donor and targets. Endosome—vesicle generated by uptake of cytoplasmic membrane and its contents. Snare proteins target vesicles by protein-protein interaction. 2. Golgi apparatus. Cis and trans faces. Modification of secreted proteins for transport to cell surface. Further glycosylation. 3. Lysosomes are membrane delimited organelles which contain hydrolytic enzymes and whose function is to degrade intracellular components (autophagy) or extracellular substances (phagocytosis) delivered by phagosomes or endosomes. Acidic pH is key to function. 4. Phagocytosis—eating large particles (bacteria; damaged cells). Endocytosis— ingesting smaller regions of membrane with receptor-ligand pairs or nutrients. Often involves recycling cell surface receptors back to surface after dropping off their cargo.
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