Lect_9_notes - Bio 1A Lecture 9 Enzymes Mechanism...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Bio 1A Lecture 9 Enzymes: Mechanism & Regulation Prof. Schlissel Feb 11, 2008 Enzyme Mechanisms and Regulation 1. Acid-base catalysis. Requires R-groups with hydrogen donors or acceptors (know these). Example of lysozyme using Glu and Asp residues to help hydrolyze glycosidic bond. 2. Enzymes can be regulated by temperature and pH. Example of proteases. Example of thermophillic proteins. 3. Allosteric regulation: binding of small molecules to enzymes alter their shape and activity. 4. Enzyme inhibitors: competitive—bind to active site; non-competitive—bind elsewhere. 5. Feedback inhibition, usually by end product of a pathway back onto first enzyme step. 6. Zymogens—inactive precursors activated by specific proteolysis 7. Regulation by covalent modification. Often by phosphorylation / dephosphorylation. Ser, Thr, Tyr can be reversibly phosphorylated, changing protein structure and activity.
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern