Bio 1A Lecture 10 Professor Schlissel February 13, 2008 Metabolism I : Glycolysis 1. Linking together exergonic and endergonic reactions to provide energy for anabolism. 2. Big picture of catabolism—complex macromolecules broken down to building blocks; building blocks funneled into glycolysis pathway, citric acid cycle, and ox-phos to generate ATP. 3. Why do cells use ATP as their predominant source of biochemical energy? Large negative Δ G o of hydrolysis due to electrostatic repulsion and resonance stabilization of Pi leaving group. Large activation energy for spontaneous hydrolysis so its pretty stable. Δ G o is in mid-range relative to other phosphate compounds. 4. NAD+ is reduced to form NADH during catabolism by accepting 2 electrons and 1 proton. NADH subsequently transfers its electrons to the electron transport chain which uses their energy to generate ATP. 5. Concept of intermediary metabolism. Interconnections between multiple pathways.
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