1st - Acne- Pharm Sci ll - Updated 2019.pptx - Overview of Acne \u2022 Acne is a skin condition that occurs when hair follicles become plugged with

1st - Acne- Pharm Sci ll - Updated 2019.pptx - Overview of...

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Overview of Acne Acne is a skin condition that occurs when hair follicles become plugged with sebum (oil), bacteria and keratin squamae (skin debris). It usually appears on the face, forehead, chest, upper back and shoulders. Acne is most common among teenagers, though it affects people of all ages . Effective treatments are available , but acne can be persistent . The pimples and bumps heal slowly, and when one begins to go away , others seem to crop up. Although acne is not physically disabling , but depending on its severity , it acne can cause emotional distress, contributing low self-esteem, depression, and anxiety and scar the skin . As a result , there is a significant demand for effective acne therapies . The earlier you start treatment, the lower your risk of such problems.
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Incidence: Acne affects all skin types , the male and female ratio is virtually the same but tends to be more severe in males . 85% affects the age group 12 – 24 years 8% affects the age group 25 – 34 years 3% affects the age group 35 – 44 years
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Causes of Acne Diagram of Hair Follicle key factors that promote the development of acne lesions are : Follicular hyperproliferation and abnormal desquamation. Increased sebum oil production Cutibacterium (formerly Propionibacterium ) acnes proliferation Inflammation
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Causes of Acne Cont Follicular Hyperkeratinization Follicular Hyperkeratinization - is a disorder of the cells lining the inside of a hair follicle . Skin keratinization causes plugging of hair follicles by dead skin cells and results in speeding up the formation of acne. Excessive sebum (oil) production Excessive sebum (oil) production causes plug the opening of the follicles which in turn leads to increase the amount of bacteria which cause inflammatory acne Androgens cause the sebaceous (oil) glands of the skin to produce more sebum (oil), excess androgens will cause excess sebum production, then acne result s . Androgens higher amounts in males, are present in females as well.
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Causes of Acne Cont.- Bacterial proliferation and Inflammation Cutibacterium (formerly Propionibacterium) acnes proliferation Cutibacterium acnes (C. acne) : is Anaerobic , gram-positive bacterium (rod) linked to the skin condition of acne. C. acnes bacteria can causes to increase production of sebum oil by hyperactive Sebaceous glands or blockage of the follicle. Large plug of sebum stimulates C. acnes bacteria to produce lipase , which breaks down (hydrolyzes) the triglycerides in the sebum oil to free fatty acids . Free fatty acids are highly irritating to the surrounding tissues , causing inflammation. Neutrophils are attracted to inflamed site, follicular wall, and release hydrolases which further causes more inflammation.
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  • Spring '17
  • Pedro Garcia

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