Copy of Bio420-Week2-9102019.pptx - Week2 Stem cells A Gulhan Ercan-Sencicek PhD [email protected] What are stem cells 1 A stem cell is an immature

Copy of Bio420-Week2-9102019.pptx - Week2 Stem cells A...

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Week2: Stem cells A. Gulhan Ercan-Sencicek, PhD [email protected] 09/10/2019
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What are stem cells? 1. A stem cell is an immature cell that can become a different cell or may become one of many different cells. 2. Most stem cells also can renew themselves by dividing indefinitely. Why should we study stem cells? Stem cells have the unique ability to replace cells and regenerate tissues affected by disease, age or trauma
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All Stem Cells Can: 1. Self renew 2. Differentiate Self-Renewal (symmetric cell division) Asymmetric type of cell division Stem Cell Stem Cell Progenitor Cell
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Stem Cell Types Embryonic – pluripotent: can form almost any cell type in the human body Tissue-Specific (Somatic or Adult) multipotent: can form only limited types of cells (blood, brain, liver, etc.) Induced Pluripotent – engineered by scientists to act like embryonic stem cells
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History Embryonic stem cells from early mouse embryos in 1981. Somatic cell nuclear transfer (SCNT) produced Dolly the sheep, the world's first cloned mammal, in 1996 (Roslin Institute in Scotland )- Stem cells from human embryos and grow the cells in the laboratory in 1998. These cells are called human embryonic stem cells. Induced pluripotent stem cells (iPSCs) in 2006
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In vitro Fertilization
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Day 1 Day 2 In Vitro Development pronuclei
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Day 3 Day4 Day5 In Vitro Development Embryonic Stem Cells The inner cells give rise to the entire body of the organism, including all of the many specialized cell types and organs such as the heart, lungs, skin, sperm, eggs and other tissues.
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This cell can form all of the cells in the human body This cell can form almost every cell type in the human body P Totipotent Pluripotent Multi- potent Fully mature The pluripotent cells are not totipotent (meaning they cannot make whole body) because the cells cannot make the placenta
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What are the unique properties of all stem cells?
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