acyclovir.doc - VALPARAISO UNIVERSITY College of Nursing N354 Nursing Care of Adult I Name_Source Davis\u2019s Drug Guide Mechanism of Action Interferes

acyclovir.doc - VALPARAISO UNIVERSITY College of Nursing...

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VALPARAISO UNIVERSITY / College of Nursing N354: Nursing Care of Adult I Name: _________________________________________Source: Davis’s Drug Guide Mechanism of Action Interferes with viral DNA synthesis Therapeutic Uses Inhibition of viral replication, decreased viral shedding, and reduced time for healing of lesions. Recommended Dosage and Route PO 200 mg q 4h while awake (5 times/day) Adverse Effects CNS: Seizues, dizziness, headache, hallucinations, trembling GI: diarrhea, N/V, increased liver enzymes, hyperbilirubinemia, abdominal pain, anorexia GU: renal failure, hematuria, renal pain DERM: stevens-johnson syndrome, acne, hives, rash, unusual swelling HEMAT: thrombotic thrombocytopenic purpura/hemolytic uremic syndrome Drug Interactions -Probenecid increases blood levels of acyclovir. Increased blood levels and risk of toxicity from theophylline; dose adjustment may be necessary. Decreased blood levels and
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