Pharmacy 4600 STUDY GUIDE.docx - Pharmacy 4600 – Fall 2019 Study Guide for the Medicinal Chemistry Exam Reaction mechanisms conversion of a sulfonyl

Pharmacy 4600 STUDY GUIDE.docx - Pharmacy 4600 – Fall...

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Pharmacy 4600 – Fall 2019 Study Guide for the Medicinal Chemistry Exam Reaction mechanisms: conversion of a sulfonyl chloride to a sulfonamide, base-promoted amide hydrolysis Definitions: hit compound, lead compound, target based assay, chemical diversity, hydrogen bonding, hydrophilic, lipophilic, log P, solubility, permeability, pKa, IC50, Z’ score Know the steps of the drug discovery process - hit compound compounds that are active in target/whole cell in vitro assays -lead compound in vivo activity -target based assay must identify a crucial biochemical process or pathway where modulation alleviates disease symptoms -Chemical diversity key in finding activity in new assays -Hydrogen Bonding solubilize a compound in water, but must be broken for the drug to cross a lipid bilayer, any binding with O or N, Specific dipole dipole interaction between H covalently bonded to an electronegative atom and another electronegative atom containing a pair of nonbonded electrons -Hydrophilic water loving, POLAR, Insoluble in nonpolar solvents like hexane and toluene, Often contain amines, carboxylic acids, or alcohols as functional groups -Lipophilic fat loving, nonpolar, often hydrocarbons -logP
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