Lecture6.pdf - Proofreading • • • • • Sometimes polymerase will make a mistake and put in the wrong base Polymerase will break the backbone

Lecture6.pdf - Proofreading • • • • • Sometimes...

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Proofreading Sometimes polymerase will make a mistake and put in the wrong base Polymerase will break the backbone and remove the wrong nucleotide and add the correct nucleotide It knows it’s the wrong nucleotide because the OH group will be in the wrong place or on an angle Sometimes proofreading fails If there is a Mismatch repair(excision repair) it will then be cut out the incorrect section and polymerase will fill in the gap It knows to do this because there is a distortion in the double helix The new strand is different from the old strand because the old strand is methalated but the new strand isnt methalated YET, if it isnt methalated it can chose the right strand if not it may chose the wrong strand and cause a mutation The piece is removed and replaced by polymerase Photons of UV light have just the right amount of energy to be trapped by Thymine's This forms a covalent bond between two thymines that are
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  • Fall '13
  • TomHaffie

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