NST10_Spr08_Lecture13 - Iron Too little Iron reduced...

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Too much Iron : a. free radical mediated damage b. susceptibility to infection c. risk of heart disease, esp. in men Fall 06 Too little Iron : reduced oxygen- carrying capacity and energy generation - especially in women, children Iron
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Free Radical : an unstable atom with an unpaired electron in its outer shell. Many factors can cause free radical formation: e.g. oxidation reactions, immune system, pollution, radiation, toxic substances
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HO--H HO--H OH - · OH H+ · H Free Radicals Ions
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Free Radical - Damage cell membrane, cellular proteins, DNA Anti-oxidants (vitamin C, E, polyphenol….) provide electrons or hydrogen atoms to free radicals to stablize them and reduce oxidative damage.
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Iron Metabolism Iron Metabolism Blood levels tightly regulated because Iron is potentially VERY toxic Two forms of iron in foods: heme iron and nonheme iron
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Heme Heme A heme is a prosthetic group (non-protein component of a conjugated protein) that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. Hemoglobin consists of 4 polypeptides chains studded with four iron-containing heme groups.
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Functions of Iron Functions of Iron 1. Oxygen transport Hemoglobin Myoglobin 2. Enzyme Cofactor More than 200 enzyme reactions 3. I mmune Function
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Iron Deficiency Iron Deficiency Mild: 1. Fatigue 2. Impaired physical work performance
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