10-02-06 (12) Cytoskeleton

10-02-06 (12) Cytoskeleton - The Cytoskeleton The...

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The Cytoskeleton
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The cytoskeleton A network of fibers extending throughout the cytoplasm that organizes the structures and activities of the cell Composed of three parts
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Microtubule 0.25 µm Microfilaments
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Roles of the Cytoskeleton: Support, Motility, and Regulation Gives mechanical support to the cell Motility Regulation of biochemical activities
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Components of the Cytoskeleton Three main types of cytoskeletal fibers Microtubules Microfilaments Intermediate Filaments
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Cytoskeletal Elements microtubule microfilament intermediate filament
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Components of the Cytoskeleton Three main types of cytoskeletal fibers Each made up of subunits Subunits held together by non-covalent (weak) interactions Accessory proteins
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Accessory Proteins Motor proteins Crosslinking proteins
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Microtubules Thickest of three cytoskeletal filaments Outer diameter of 25 nm Long hollow cylinders Straight and rigid Made from the protein tubulin
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Microtubules
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Microtubules Made from tubulin The subunit is a tubulin heterodimer Subunits join noncovalently Each microtubule is composed of 13 protofilaments
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Microtubules
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The Centrosome The centrosome is the “microtubule- organizing center” (MTOC) Microtubules grow out of centrosome Contains a pair of centrioles
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