Running head: KETAMINE AS AN ADJUNCT TREATMENT FOR DEPRESSION 1 Ketamine as an adjunct treatment for depression: A review of current literature Keith Smith University of Texas at Arlington Principles of Research in Nursing NURS-5366-400 Denise Cauble, PhD, RN, CWOCN
KETAMINE AS AN ADJUNCT TREATMENT FOR DEPRESSION 2 Ketamine as an adjunct treatment for depression: A review of current literature Major depressive disorder (MDD) is a prevalent and deadly disease. Approximately 34 million Americans alive today will experience MMD within their lifetimes (Kessler et al., 2003). Of those, about 30% will not respond to traditional medication and treatment (Rush et al., 2009). Most traditional antidepressant medications can take two weeks or longer to become effective. Recent studies have shown ketamine to be very effective in alleviating symptoms of MDD and suicidal ideation (SI) in as little as 40 minutes after infusion with results that last up to a week or more (Burger et al., 2016; Ionescu et al., 2018; Kheirabadi, Vafaie, Kheirabadi, Mirlouhi, & Hajiannasab, 2019; Nugent, Wills, Gilbert, & Zarate, 2018). Most studies concentrate on the effects of ketamine alone. However, little evidence exists to show how ketamine can be used as an emergency medication for acute SI to help curb depressive symptoms in the interim until traditional medication and therapy can take effect.
KETAMINE AS AN ADJUNCT TREATMENT FOR DEPRESSION 3 PINCH Table Author(s) last name and year Study Purpose Sample (N=xx) and Demographics Describe the sample in detail. Study Design type (describe in detail) & Variables (List variables and label as Research, IV, DV) Define your variables. Measurement methods of variables (tools, surveys or scales). Give detailed descriptions, reliability and validity. Major Study Findings / Results (include some statistics and whether they are significant or not) Notes Burger, Capobianco, Lovern, Boche, Ross, Darracq, and McLay (2016) The purpose of this study is to help prove that Ketamine can help military serve members with acute suicidal ideation. The researchers recruited a convenience sampling of (n=18) active duty military that reported to the Naval Medical Center ED in San Diego. Participants ranged from 18- 65 years old with BSS>4, BHS>8, and BDI>19 that were not pregnant and were able to give informed consent.
- Fall '16
- Denise Cauble