Chapter 24 PowerPoint.ppt - Spencer L Seager Michael R Slabaugh www.cengage.com/chemistry/seager Chapter 24 Lipid and Amino Acid Metabolism Jennifer P

Chapter 24 PowerPoint.ppt - Spencer L Seager Michael R...

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Chapter 24: Lipid and Amino Acid Metabolism Spencer L. Seager Michael R. Slabaugh Jennifer P. Harris
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LIPID METABOLISM – BLOOD LIPIDS During digestion, lipids are hydrolyzed to glycerol, fatty acids, and monoglycerides. For transport in the lymph and blood, the cells of the small intestines produce lipoprotein aggregates called chylomicrons .
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LIPID METABOLISM – BLOOD LIPIDS (continued) Behavior of blood lipids parallels that of blood sugar. The concentrations of both increase after a meal. The concentrations of both return to normal as a result of: storage in fat depots. oxidation to provide energy. Plasma lipids concentrations: rise within 2 hours of a meal. reach a peak in 4-6 hours. drop rapidly to a normal level.
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BLOOD LIPID CLASSIFICATION Lipids are less dense than proteins. The classification of blood lipids is based on density. The higher the lipid concentration of a lipoprotein aggregate, the lower the density. VLDL = very low density lipoprotein LDL = low density lipoprotein HDL = high density lipoprotein
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SCHEMATIC MODEL OF LDL
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FAT MOBILIZATION (continued) Fatty acids stored in triglycerides are called on as energy sources: after a few hours of fasting. even when glycogen supplies are adequate by resting muscle and liver cells, because it: conserves the body’s glycogen stores and glucose for brain cells and red blood cells. Brain cells do not obtain nutrients from blood. Red blood cells do not have mitochondria; therefore, red blood cells do not have fatty acid oxidation.
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FAT MOBILIZATION (continued) Triglycerides are stored in adipose tissue . Several hormones, including epinephrine, stimulate fat mobilization when body cells need fatty acids for energy. Fat mobilization entails the hydrolysis of stored triglycerides into fatty acids and glycerol which then enter the bloodstream. In blood, mobilized fatty acids form a lipoprotein with the plasma protein called serum albumin. Fatty acids transported to tissue cells that need them in this form. Glycerol produced from triglyceride hydrolysis is water soluble.
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