dbott_coagmed_11022019.docx - Medications affecting...

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Medications affecting coagulation Coumadin Heparin Lovenox Mode of Action Interrupts vitamin K dependent clotting factors Stops the effects of anti- thrombin Stops effects of anti- thrombin on factor Xa and thrombin Indications Prophylaxes, Tx of venous thrombosis, PE, AFib, management of MI, prevention of thrombus formation Prophylaxis, TX of venous thromboembolism, PE, A-Fib, peripheral arterial thromboembolism Prevention of venous thromboembolism, DVT, PE, ischemic complications Dosage/Route PO 2-5mg/day then adjust according to INR IV intermittent bolus 10,000 U then 5,000 U q4-6 hours, continuous infusion 1,000U/hr SubQ 30mg q12hr IV 30mg Side Effects Dermal necrosis, bleeding, cramps, nausea, calcification of small blood vessels, fever Drug induced hepatitis, bleeding, heparin induced thrombocytopenia, anemia Dizziness, HA, insomnia, bleeding, anemia, increased liver
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Unformatted text preview: enzymes, hematoma Labs to Monitor PT, INR, hepatic function, CBC aPTT, HCT, platelet count, Potassium, AST, ALT CBC, platelet, occult blood, aPTT for some, AST, ALT, potassium, Antidote Vitamin K Protamine Sulfate Protamine Sulfate Patient teaching Limited intake of Vitamin K foods, avoid cranberry juice, avoid IM injections and activities that could lead to injury, report unusual bruising and bleeding. Do not drink alcohol and routine labs to monitor coag factors. Report and signs of unusual bruising or bleeding, do not take NSAIDS or aspirin, avoid IM injections, carry an ID card Technique for self-injection, unusual bruising and bleeding should be reported, no naproxen, ibuprofen, or aspirin Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2019). Daviss drug guide for nurses. Philadelphia, PA: F.A. Davis Company....
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