Wnt Pathway.pptx - WNT PATHWAY MBG403 Developmental Biology Taha Buğra Güngül Melisa Çetinkaya İlayda Erakın Eren Gülümser Perge Bilgesu

Wnt Pathway.pptx - WNT PATHWAY MBG403 Developmental Biology...

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WNT PATHWAY MBG403 Developmental Biology Taha Buğra Güngül Melisa Çetinkaya İlayda Erakın Eren Gülümser Perge Bilgesu Tosunoğlu
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Introduction 2 What is a Wnt protein and its role? 1980 – Drosophila and Mus musculus Growth factors Cysteine-rich proteins Cell proliferation, cell polarity and cell fate Figure 1. Space-filling model of XWnt8 as an example. (Willert, K. & Nusse, R. , 2012)
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Canonical Pathway 3 Figure 2. Canonical pathway of WNT at on (a) and off (b) states.
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Non-Canonical Pathways 4 Non-canonical pathways Wnt/Ca 2+ Wnt/PCP Figure 3. Schematic representation of non-canonical pathways classification
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Wnt/Ca 2+ Signaling Pathway 5 Figure 4. The mechanism of non-canonical Wnt/Ca 2+ signaling pathway.
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Wnt/PCP Signalling Pathway 6 Figure 5. The mechanism of non-canonical Wnt/PCP signalling pathway.
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The Role of Wnt Pathway in Early Development and Organogenesis 7 A) Canonical Pathway - Early Development & Organogenesis -correct specification to different cellular lineages -meso-endodermal lineage in the post-implantation blastocyst stage -differentation -axis determination
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The Role of Wnt Pathway in Early Development and Organogenesis 8 A) Overview of mouse pre- implantation and post- implantation developmental stage B)Molecular changes is Wnt signaling C)Pre-gastrulating mouse embryo Figure 6. Tracing of Wnt signaling in early mouse embryogenesis (de Jaime-Soguero, A., Abreu de Oliveira, W. A., & Lluis, F., 2018)
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