w4_specification.pdf - Specification Introducing cell commitment and early embryonic development Specification Differentiation is generation of

w4_specification.pdf - Specification Introducing cell...

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Specification Introducing cell commitment and early embryonic development
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Specification Differentiation is generation of specialized cell types. 2
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Specification Differentiation is preceded by commitment , which is the process during which developmental fate is being restricted. The cell may not represent any phenotype even if it is committed. There are two stages of commitment; (i) specification Cell has the capacity to autonomously differentiate when placed into a neutral environment It is reversible (ii) determination Cell has the capacity to autonomously differentiate even when it is placed into a non-neutral environment (irrelevant region of embryo) It is irreversible 3
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Specification 3 major strategies of commitment: (i) autonomous specification (ii) conditional specification (iii) syncytial specification 4
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Specification Autonomous specification Egg cytoplasm is not homogeneous.
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