NURS 6630, Week 1 discussion.edited.docx - NURS 6630 Main Question Post Week 1 Introduction to Neuroscience Agonist-to-Antagonist Spectrum of Action

NURS 6630, Week 1 discussion.edited.docx - NURS 6630 Main...

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NURS 6630 Main Question Post, Week 1 Introduction to Neuroscience Agonist-to-Antagonist Spectrum of Action Psychopharmacologic drugs work at the sites of neurotransmission and their effects are based on a spectrum of agonist to an antagonist. An agonist is a molecule that is similar to the effects of a neurotransmitter by binding and stimulating the receptor site to produce a response (Stahl, 2013). An antagonist opposes the outcome of the agonist, by blocking the action of neurotransmission. Antagonists are known as the mediators of therapeutic actions in psychiatric disorders and as the cause of undesirable side effects (Stahl, 2013). The spectrum of agonist to antagonist consists of a full agonist, partial agonist, silent antagonist, and inverse agonists (Stahl, 2013). A full agonist allows the receptor to fully open the ion channel, which provides signal transduction to occur. A partial agonist occurs when the receptor has a resting state. Next, on the spectrum, the silent antagonist will return the receptor to a resting state. The last type on the range is the inverse agonists which cause receptor change and the closing of ion channels. Depending on where on where a particular psychopharmacological drug is on the agonist-to- antagonist spectrum, determines its interaction with the targeted receptor. G Couple Proteins and Ion Gated Channels.
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