Acute Myeloid Leukemia - Noor Fariss Basics of Acute...

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Noor Fariss Basics of Acute Myeloid Leukemia Acute Myeloid Leukemia (AML) is a rare type of cancer of the blood and bone marrow with a overabundance of white blood cells (leukocytes), red blood cells, or platelets.There are fewer than 200,000 US cases per year.AML starts in the bone marrow and will infect not-yet fully developed cells and they become abnormal and double in size. They start building up in the bone and that very little space for actual healthy cells,causing the skin to easily bleed and/or bruise. They can quickly move on into the bloodstream as well as the central nervous system (brain and spinal cord), skin, and the gums. People with AML experience symptoms such as: Fatigue Recurrent Infections Bruising Easily Bleeding Infection Fever Extremely Pale Skin Red Spots on the Skin Shortness of breath How the Mechanism is Supposed to Work There are 3 parts to a transduction pathway: reception,transduction,and response. 1. Reception - Is like when a phone is ringing. Its is when a molecule binds to the membrane receptor protein. This molecule is called the ligand. A ligand refers to the actual signal molecule that binds to the receptor protein on the cell membrane or inside the cell. 2. Transduction - Is like answering the phone. Transduction is a series of steps that change a signal into something the cell can understand at the nucleus or in the cytoplasm. 3. Response - Is like Hanging up the phone. It involves making something or turning on/off an enzymatic process. It usually involves DNA transcription and translation or enzymes inside the cell.
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