Marcus Raichle Transcript.doc - OMR Conversations Marcus Raichle M.D[music[00:00:10 We are in Boston at the Sheraton which is the headquarters for an

Marcus Raichle Transcript.doc - OMR Conversations Marcus...

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OMR Conversations Marcus Raichle, M.D. [music] [00:00:10] We are in Boston at the Sheraton, which is the headquarters for an amazing meeting called One Mind for Research. It’s been described as a moonshot into the mind. One of the panels this morning was a symposium called “Connectome, Mapping the Brain” and one of the speakers in that panel who talked about the human brain at work was Marcus Raichle who is a neurologist, professor of radiology, neurology, neurobiology and biomedical engineering at Wash U, St. Louis. So, welcome. Thank you. The theme, the thrust of your story this morning, as I listened to it, was the brain’s basically in the prediction business. Correct. And you also gave some amazing stories about self-control and impulsivity in juvenile offenders. Those are the two things I wanted to get to, remind us to talk about, but Patrick had set the scene first of all, since you’re one of the founders of the field of brain mapping, PETs and FMRI and so on, give some sense of where you think the field really is at, at this point, and how effective it is. [00:01:17] Oh, I can give you a sense of where I think it might be going. We entered this field as almost a parallel to neurobiology in the past in terms of mapping functions in the brain, whether you put an electrode in or you look at it with some optical or whatever your technique was, the basic paradigm was to have a task or have a stimulus or something and you looked at what the brain did when you delivered the stimulus. You turned something on and if you were privy to the behavior you tried to correlate all of this. So, this was a, very much an idea that certainly can be traced back to people like Sir Charles Sherrington who, later in his life, I think, migrated somewhat from that, but he was well known for this view - that we’re thinking about it as a reflexive system. That it’s waiting for something to happen and then it engineers a response. And interestingly enough, actually in the symposium on perception this morning, that was kind of the paradigm that introduced that section. And it’s been hugely productive, I mean, in the brain, again, people talk about Hubel and Wiesel and how much we learned from that paradigm, but as the imaging story evolved and we followed that and developed many of the tools that were – paralleled that by putting people in scanners and asking them to do things. So, things came up along the way. One of them was the realization that as good as we were at seeing these changes in the brain, they were incredibly small. They just didn’t represent a very big change. Page 1
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Surely, they must be important, but they weren’t very big. And that was one of the things I wanted to illustrate this morning. [00:03:06] And so, then the question was, you have this organ sitting there and it’s one of the most expensive organs in the body. It chews up 20% of the cost of running the body. And the question is, well, if the changes that we can elicit are a few percentage locally, then what in the world is going on with the rest of this?
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  • Spring '14
  • JenniferM.Bloomberg

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