Midterm II Study Guide - Su 18 - Midterm II Summer 2018 Study Guide – DRAFT Protein Sorting • • • • • • Cytosolic translation versus

Midterm II Study Guide - Su 18 - Midterm II Summer 2018...

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Midterm II - Summer 2018 Study Guide – DRAFT Protein Sorting Cytosolic translation versus secretory protein translation Targeting of proteins o Movement of polypeptide chains into ER SRP receptors, SRP proteins N-terminal sequence hydrophobic + positive charges What differentiates proteins that stay in the ER vs proteins that leave the ER? What is different between ER protein translocation in yeast vs other eukaryotes? What marks proteins that will go to the Lysosome? o Insertion of proteins into the ER membrane Know the differences between Type I, II, III and IV. Be able to draw types I, II, III and explain their insertion in the ER. Also, be able to draw how they look like in the plasma membrane. o Targeting of cytosolic proteins to different organelles Mitochondria Matrix targeting sequence Import into mitochondria Import into the mitochondrial matrix o Simultaneous transfer Chloroplast (only what was covered in lecture) Nucleus What are nuclear pores? Ran cycle with GDP and GTP. Role of RanGEF and RanGAP. What ensures that the cycle is unidirectional? What are the other factors involved? [Import and Export] Importins; Exportins o What are the sources of energy in each case?
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