nested case control vs case control study.pdf - Volume 22 Number 1 February/March 2016 Case-Cohort Studies vs Nested Case-Control Studies Soyoung Kim

nested case control vs case control study.pdf - Volume 22...

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Volume 22, Number 1, February/March 2016 ________________________________________________ _____________________________________________________________________________________ © 2016 by Division of Biostatistics, Medical College of Wisconsin Case-Cohort Studies vs Nested Case-Control Studies Soyoung Kim, PhD, Division of Biostatistics, MCW A cohort study is one of the observational study designs which is used to evaluate association between exposure and disease. In a cohort study, investigators follow a group of people over time and note each new occurrence of the disease. However, large epidemiologic cohort studies often need to follow several thousand subjects for a long time. Assembling detailed information for all cohort members may take a long time and result in an enormous cost. To reduce cost and achieve the same goal as a cohort study, several alternative study designs have been proposed. Some of them such as nested case-control and case-cohort study designs are particularly practical in studying rare diseases. A nested case-control study design involves the selection of several healthy controls for each
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