Arosols.pdf - Page 1 of 32 Pharma Tech V Chapter 5 Aerosols Syllabus Pharmaceutical Aerosols Definition propellants general formulation manufacturing

Arosols.pdf - Page 1 of 32 Pharma Tech V Chapter 5 Aerosols...

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Page 1 of 32 By PARAMJOT Source: Google, lackman, Pdfs, Remington, PPTs, pubmed, Scienedirect, A.K. seth, Subramanyum etc. Pharma Tech V: Chapter 5 Aerosols Syllabus: Pharmaceutical Aerosols: Definition, propellants, general formulation, manufacturing and packaging methods, pharmaceutical applications.
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Page 2 of 32 By PARAMJOT Source: Google, lackman, Pdfs, Remington, PPTs, pubmed, Scienedirect, A.K. seth, Subramanyum etc. Defination: 1) An aerosol is defined as a colloidal system of solid or liquid particles in a gas. 2) A system that depends on the power of a compressed or liquefied gas to expel the contents from the container. 3) An aerosol is a pressurized dosage form containing one or more therapeutic active ingredients which upon actuation emit a fine dispersion of liquid and/or solid materials in a gaseous medium of size smaller than 50 μm. Advantages of aerosols: 1) Stability can be enhanced for those substances adversely affected by atmospheric oxygen or moisture. 2) A specific amount of dose or drug can be removed from the container without contamination of remaining contents. 3) The onset of action is faster compared to other dosage forms because the medicament is directly applied to the affected area part. 4) Required quantity of contents can be easily withdrawn from the package without contamination or exposure of the remaining material. 5) Irritation can be reduced by application of topical aerosol medication in a uniform thin layer to the skin without touching the affected area. 6) Sterility can be for sterile product, because no microorganism can enter even when the valve is opened. Disadvantages of aerosols: If the drug is not soluble in the propellant, aerosol the formulation is difficult. Sometimes propellants may cause toxic reactions, if therapy is continued for a long period of time. High cost Aerosol packs must away from temperature and fire, because it may develop high pressure inside the container leads to explosion. Components of Aerosol packaging: 1) Propellant 2) Product Concentrates
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Page 3 of 32 By PARAMJOT Source: Google, lackman, Pdfs, Remington, PPTs, pubmed, Scienedirect, A.K. seth, Subramanyum etc. 3) Container 4) Valve and Actuator 1) Propellants: Propellants are responsible for developing the pressure in the aerosol container and also it expel the product from the container when the valve is opened and helps in expels the product. Types of propellant: Depending on use of propellants, the propellant can be classified as 1) For oral and inhalation (Fluorinated hydrocarbons), Examples Tri-chloro-mono-flouro methane (propellant 11) Di-chloro di-fluro methane (propellant 12) Di-chloro tetra-fluro ethane (propellant 114) 2) Topical Pharmaceutical aerosols (Hydrocarbon propellants), Examples Propane Butane Isobutane Depending on Physical Nature of propellants, the propellant can be classified as I) Liquified Gas Propellants, Example, Tri-chloro-mono-flouro methane (propellant 11) Di-chloro di-fluro methane (propellant 12) Di-chloro tetra-fluro ethane (propellant 114) II) Compressed Gas Propellants. Example,
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  • Winter '18
  • roheeda khan

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