Data Analysis in Medicine32.pdf - Enriched Regression 1 1 Introduction In most research settings in medicine we aim at knowing the effect of a certain

Data Analysis in Medicine32.pdf - Enriched Regression 1 1...

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Enriched Regression 1 1. Introduction In most research settings in medicine, we aim at knowing the effect of a certain exposure to the risk of some specific disease among a well-defined targeted population. To achieve this goal, well-designed trials are usually used. However, the sample sizes for such studies are usually limited due to the high cost of recruitment and thus the sample size usually just have power to detect the effect for the primary exposure of interest. In the mean time, the number of available observational studies or trial studies from other population are accumulated quickly nowadays. Can we use information from these data to improve our inference on the population where small data is drawn from? Here we refer the randomized clinical trial data which have a clearly defined target population by the design and sampling scheme as “small data” and refer other external data as “big data”. Our goal is to efficiently
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