L&S C30T Lec7 - L&S 30 Lecture 7 Penecillin won't cross...

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L&S 30 Lecture 7 Penecillin won’t cross blood -brain barrier Drug injected (morphine) need to be soluble but hydrophobic enough so it can cross blood-brain barrier Hydrocarbon chain CH 4 methane Simplest hydrocarbon Dopamine 6 carbons Similar to amphetamine Dopamine does not cross blood-brain barrier, but amphetamine can Dopa is chemical precursor to dopamine, effective in getting in brain Human body Central nervous system (CNS) brain & spinal cord Peripheral nervous system (PNS) somatic nervous system muscle, entric, sensory autonomic nervous system and somatic nervous system nicotine, etc. bad because of effect on autonomic nervous system, not brain Sympathetic activated by worry, stress Increases heart rate Increase blood pressure dilates lung airways Dilates pupils of eyes Constricts bladder Decreases intestinal motility Neurotransmitter: norepinephrine Parasympathetic (opposite)
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