L&S C30T Lec13 - L&S C30T Drugs in the Brain...

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L&S C30T Drugs in the Brain Lecture 13: Alcohol Debate #3 The psychoactive plant Salvia divinorum and its primary psychoactive component molecule, Salvinorin A, should be classified as Schedule One Controlled Substance. Therapeutic Index Measure of acute (short-term) toxicity of the drug Consume alcohol in short period of time can lead to death Therapeutic Index (TI) = lethal dose ÷ therapeutic dose Drugs to treat various conditions Aspirin, 600 mg LD50 Reduce ability of blood to clot Hemorrhaging Aspirin overdose Prozac safe in overdose as opposed to old antidepressants Drugs with lower TI are less safe Alcohol Lethal dose = 0.40 BAC If no tolerance, may be lower Therapeutic dose = 0.04 BAC Relaxation, enjoyment Can legally drive at 0.08 Therapeutic index = 0.40 BAC ÷ 0.04 BAC = 10 Very low therapeutic index 10x alcohol to kill you as to pleasantly intoxicate you If it is a new drug, FDA requirement is to determine TI based on animals If TI is from 10-15, FDA would say no Short-term death with alcohol if high enough dose Opiod TI may be lower than alcohol Nicotine LD 60 milligrams, absorb from cigarette is several milligrams for 20-25 TI 2006 Alcohol prevalence data Persons over 12 years of age Ever use alcohol = 83% (204 million) Use alcohol in past year = 66% (163 million) Use alcohol in past month = 51% (126 million) Does not say how much At least 15% of current users have alcohol abuse problems Underestimate because will not admit Economic cost of alcohol abuse in USA > $150 billion per year
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Auto accidents: ~50% alcohol related
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L&S C30T Lec13 - L&S C30T Drugs in the Brain...

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