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Article 1:1.Reference:Bailey RI, Mills JI, Yetley EA, et al. Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged ≥60 y in the United States. Am J Clin Nutr. 2010; 92(2):383-389. . Accessed June 16, 2019.2.Study design: Cross-Sectional Study3.a) Exposures/risk factors measured (independent variables): Unmetabolized serum folic acid (UMFA) concentrationsb) Outcomes measured (dependent variables): Folic acid intake from diet and supplements4.Evaluation of the use of biochemical indicators of dietary intake: The study used UMFA concentrations in relation to dietary and supplemental folate intake to understand their relationship to the possible development of a disease, in this case cancer risk. Biochemical indicators and data were gathered with the use of the National Health and Nutritional Examination Survey (NHANES) from 2001-2002, which is a nationally representative survey (n