HW3 - one of the following ways ammonia urea or uric acid...

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BME 221 Homework #3, Sept 20, 2007 1) Read pages 49-72 in the Atkins DePaula book 2) Answer the following problems from Atkins, DePaula: 1.26 3) 1.27 4) 1.30 5) 1.31 6) 1.34 7) 1.36 8) You have been asked to investigate the thermodynamic properties of a newly identified small globular protein by differential scanning calorimetry. The following results were obtained (T m = melting temperature of the protein; H d (Tm) = change in enthalpy during denaturation of the protein at the melting temperature): pH T m (ºC) ΔH d (T m ) (kJ mol -1 ) 2.0 68.9 238 2.5 76.1 259 3.0 83.2 279 3.5 89.4 297 4.0 92.0 305 4.5 92.9 307 5.0 93.2 308 5.5 91.3 303 6.0 88.9 296 6.5 85.9 287 7.0 82.0 276 7.5 79.4 268 8.0 77.8 264 a) Determine C p of protein unfolding. b) Construct a plot of H d (Tm) as a function of pH. What does this plot tell you? 9) Living organisms excrete excess nitrogen from the metabolism of amino acids in
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Unformatted text preview: one of the following ways: ammonia, urea, or uric acid. Urea is synthesized in the liver by enzymes of the urea cycle, excreted into the bloodstream, and accumulated by the kidneys for excretion in urine. The urea cycle – the first known metabolic cycle – was elucidated in outline by Hans Krebs and Kurt Hensleit in 1932. Urea is a strong chemical denaturant that is used to study the structural stability or proteins. Solid urea combusts to liquid water and gaseous carbon dioxide and nitrogen according to the following reaction scheme: CO(NH 2 ) 2 (s) + 1.5 O 2 (g) CO 2 (g) + N 2 (g) + 2 H 2 O (l) According to bomb calorimetry measurements, at 25ºC this reaction results in the release of 152.3 kcal mol-1 . Calculate ΔH for this reaction....
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