2018 F BIOL230 L8-4.pdf - Cell Junc/ons and Extracellular Structures Organisms Unicellular Mul/cellular Tissues • Cell-­‐cell contact • Cell

2018 F BIOL230 L8-4.pdf - Cell Junc/ons and Extracellular...

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Unformatted text preview: 9/20/18 Cell Junc/ons and Extracellular Structures Organisms Unicellular Mul/cellular Tissues • Cell-­‐cell contact • Cell adhesion • Cell Junc/ons • Extracellular matrix 1 9/20/18 Types of cell-­‐cell adhesion molecules Homotypic (or homophilic) interac/on Homotypic (or homophilic) interac/on Heterotypic (or heterophilic) interac/on Heterotypic (or heterophilic) interac/on Belong to Ig (immunoglobulin) superfamily NCAM = Neuronal Cell Adhesion Molecule, involved in neuronal development and growth Muta/ons – mental retarda/on 2 9/20/18 E cadherin – epithelial. Embryonic development, /ssue forma/on. Express – adhesion, KO – not. N-­‐cadherin – synapses. Requires Ca2+ for adhesion. Figure 17-­‐2b Glycosyla/on –very important P-­‐selec/n – on platelets and endothelial cells L-­‐selec/n -­‐ on leucocytes, involved in leucocyte rolling. Figure 17-­‐2c 3 9/20/18 Junc/ons between animal cells Table 17-­‐1 Adhesive junc/ons : Cell-­‐cell and cell-­‐ECM Figure 17-­‐7 4 9/20/18 Adherence junc/on Connect to cytoskeleton Involved in cancer signaling Figure 17-­‐3 Desmosome (very strong adhesion, structural) Figure 17-­‐3 5 9/20/18 Naxos disease two causa/ve genes, encoding for the proteins plakoglobin and desmoplakin Cardiomyopathies with a cutaneous phenotype, characterized by woolly hair, progressive heart disease Tight junc/on, Claudins 6 9/20/18 Claudins and pericellular transport pathway Claudins (about 12 different ones) Dynamic interac/on Selec/vity for ca/ons Figure 17-­‐10 Organisms Unicellular Interac/on with host Interac/on with each other Mul/cellular Tissues • Cell-­‐cell contact • Cell adhesion • Cell Junc/ons • Extracellular matrix 7 9/20/18 Bacteria and cell adhesion proteins Yersinia (from water and food): Listeria (from raw meets): 25% cases lethal gastroenteri/s, Bacterial meningi/s vomi/ng, diarrhea 24-­‐8h afer exposure Figure 17A-­‐1 Adenovirus and cell adhesion 8 9/20/18 Extracellular structures cellulose Important extracellular matrix proteins Collagen -­‐ strength Elas/n -­‐ flexibility Fibronec/ns-­‐ cell shape, movement, blood clojng Laminins-­‐ cell akachment to connec/ve /ssue Integrins – connect extracellular matrix and cytoskeleton 9 9/20/18 Fibronec/n Soluble in blood, binds fibrin, platelets akach to fibrin Development (/ssue forma/on) Cell movement, akachment and shape Figure 17-­‐17 Laminin Present in basal lamina. Defects lead to muscular dystrophy, intes/nal, and kidney disease. Figure 17-­‐19 10 9/20/18 Integrins Interac/on with fibronec/n Focal adhesion Inside out signaling Anchorage-­‐dependent growth Figure 17-­‐21 Collagen structure Figure 17-­‐13 11 9/20/18 With age, collagen fibers get crosslinked and inflexible Figure 17-­‐14 EHLERS-­‐DANLOS SYNDROME Collagen I and III defects 12 9/20/18 Elas/n Wound healing With age, elas/n loss from skin Figure 17-­‐15 Marfan Syndrome The build of his hand was peculiar, as we learn from his personal physician, Dr. Benna/, who published his findings in 1831: “Paganini's hand is not larger than normal; but because all its parts are so stretchable, it can double its reach. For example, without changing the posi/on of the hand, he is able to bend the first joints of the lef fingers -­‐-­‐which touch the strings-­‐-­‐sideways, at a right angle to the natural mo/on of the joint, and he can do it with effortless ease, assurance, and speed. Essen/ally, Paganini's art is based on physical endowment, increased and developed by ceaseless prac/cing.” 13 9/20/18 Hypermobility Harry Houdini 14 ...
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