telomerase and functions.ppt - Telomerase and the...

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Telomerase and the consequence of telomere dysfunction AAAS Annual meeting February 19 th 2010 Carol Greider Daniel Nathans Professor & Director Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine
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Telomeres and Telomerase: Bridging Science and Society Curiosity driven research establishes fundamental knowledge that fuels practical applications.
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Telomeres are the ends of chromosomes Protect ends Maintain length
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Tetrahymena thermophila : single celled animal with 40,000 chromosomes Elizabeth Blackburn & Joe Gall (1978): Defined telomere sequence as tandem repeats of TTGGGG
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Replication Replication Replication TTGGGG
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Nature July 1984 Maintain linear plasmid in yeast Telomere Marker Ori Remove right telomere Add yeast genomic DNA Yeast telomeres stabilizes linear plasmid Tetrahymena and yeast: conservation of telomere function & telomere elongation
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Telomerase activity identified
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Replication Telomerase allows telomere length equilibrium maintenance Telomerase TR TERT
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Why does telomerase matter? Cancer Tissue renewal It is required for cells that must divide many times
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Nature May 1990 Telomere shortening in cellular senescence
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Vaziri et al. AJHG (1995) Telomeres shorten with age Telomerase is Telomerase is limiting in cells limiting in cells
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Using laboratory mice to probe telomere function
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