Cancer II Outline.docx - Cancer II • Define key terms associated with cancer pathophysiology-Invasion Metastasis Cancer can spread several ways 1

Cancer II Outline.docx - Cancer II • Define key terms...

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Cancer II Define key terms associated with cancer pathophysiology -Invasion & Metastasis Cancer can spread several ways: 1. Direct invasion of tissues. 2. Seeding of cancer cells into neighboring tissue of distant tissues 3. May occur through blood or lymph vessels “Cancer” – named for its crab-like projections Localized Disease: Clinically defined as a cancer that is limited to the tissue or organ in which it began. Regional Disease: Cancer that has grown beyond the original tumor and spread to nearby lymph nodes or tissues. Metastatic Disease (Distant, remote, diffuse, disseminated or secondary) Cancer that has spread to and colonized tissue and/or organs distant to it origin. Tissue Invasion: Cancer cells produce various proteases The key proteases being the matrix metalloproteinases (MMPs) MMPs digest the extracellular matrix (ECM) ECM is proteins and other macromolecules that hold tissues together Physical barriers to cell migration ECM digestion facilitates invasion into surrounding tissue.
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  • Fall '14
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