1_02_Lecture_3_resource.pdf - Dr Suzanne Ollerenshaw Histology of connective tissue and muscle 2017 COMMONWEALTH OF AUSTRALIA Copyright Regulations 1969

1_02_Lecture_3_resource.pdf - Dr Suzanne Ollerenshaw...

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COMMONWEALTH OF AUSTRALIA Copyright Regulations 1969 WARNING This material has been reproduced and communicated to you by or on behalf of the University of Sydney pursuant to Part VB of the Copyright Act 1968 (the Act). The material in this communication may be subject to copyright under the Act. Any further reproduction or communication of this material by you may be the subject of copyright protection under the Act. Do not remove this notice Dr Suzanne Ollerenshaw Histology of connective tissue and muscle 2017
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Learning Objectives 1. Define the term “connective tissue” 2. List the constituents of connective tissue 3. Characterise collagen and elastin fibres 4. Describe the histological features and functions of fibroblasts 5. Identify the types of permanent and transient cells in CT 6. Outline the main features of loose and dense CT and know examples of tissues in which each can be found 7. Be able to differentiate between the different cells in Blood and know their functions 8. Describe the structure of skeletal muscle at both the light and electron microscope level 9. Describe the structure of smooth muscle at different orientations 10.Describe the structure of cardiac muscle and how it differs from skeletal muscle
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CONNECTIVE TISSUE The cells and extracellular materials that provide the support and connecting framework for all the other tissues of the body
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CONNECTIVE TISSUE FIBRES insoluble, in a network collagen elastic reticular CELLS variable number & types fibroblast immune cells MATRIX water (ground substance) proteoglycans electrolytes
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Connective Tissue - classification Proper Specialized Loose Dense Adipose Blood Bone Cartilage Lymphatic irregular regular
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Loose, irregular connective tissue Often located under an epithelium Fibroblasts produce the fibres & ground substance Inflammatory cells Small blood vessels Peripheral nerves lamina propria
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Dense, regular connective tissue Dense, irregular connective tissue Collagen Fibres Fibroblast nuclei Fibroblast Nuclei Collagen Fibres in bundles Tendon submucosa
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(1) Lamina propria (2) Submucosa (3) Dermis (4) Tendon 1 2 3 4 3
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FIBROBLASTS stained with H+E Produce fibres and matrix Spindle shaped Flattened nucleus
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FIBROBLAST with transmission electron microscope Collagen fibrils
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Mast Cells 20-30μm diameter Oval shaped cell Large cytoplasmic granules Small round nucleus Many small surface projections Macrophages 15-80μm diameter Cytoplasmic projections with course granules Eccentric nucleus Adipocytes Round cells
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