BIOL 1000 Lect 24.docx - BIOL 1000 Oct 24 26 29 >Pyruvate Oxidation-Pyruvate carried across membrane into matrix-Get pyruvate into a matrix-Converting

BIOL 1000 Lect 24.docx - BIOL 1000 Oct 24 26 29 >Pyruvate...

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BIOL 1000- Oct 24 & 26 & 29 >Pyruvate Oxidation: -Pyruvate carried across membrane into matrix -Get pyruvate into a matrix -Converting each pyruvate into Acetyl COA -Creating 2 NADH per pyruvate molecule -Under enzymatic control of pyruvate dehydrogenase complex (complex-made of 3 subunits) -Decarboxylation: removing the carboxyl group creation of CO2, three carbon molecule to two carbon, CoA protein added (Acetyl-CoA coming from), removal of hydrogen >Citric Acid Cycle (Krebs Cycle) What is the primary purpose of the Citric Acid Cycle? A)Transfer energy, originally assoc with glucose into other molecules -> Take energy remaining from glucose and convert into other molecules (useable energy molecules) -What start with is what have to end with (cycle) -Starts with 4 carbon molecule oxaloacetate then must end with oxaloacetate, Acetyl-CoA react (2 carbon) into Citrate (6 carbon)---- isomerase-- Isocitrate -The first NADH created, carbon removed from Keto glutarate and carbon removed attaching to O2 to make CO2 -CoA-SH added creating a high energy bond and phosphate added (Pi) to carbon creating high energy phosphate bond (CoA off, inorganic phosphate on) *substrate level phosphorylation by GTP -Succinate (4 carbon) -creation of FADH2 from FAD
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