28 INNATE RESISTANCE FL 19.pptx - HOST DEFENSES – INNATE/NON-SPECIFIC/GENERAL RESISTANCE GOAL IS TO LIMIT/ELIMINATE ANY INFECTION A B C PHYSICAL

28 INNATE RESISTANCE FL 19.pptx - HOST DEFENSES –...

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HOST DEFENSES – INNATE/NON-SPECIFIC/GENERAL RESISTANCE GOAL IS TO LIMIT/ELIMINATE ANY INFECTION A. PHYSICAL BARRIERS B. CHEMICAL BARRIERS C. PHAGOCYTOSIS 1. BLOOD COMPONENTS AND CIRCULATION 2. BLOOD CELLS AND HEMATOPOEISIS BLOOD CELL FORMATION/DEVELOPMENT 3. PHAGOCYTOSIS MECHANISM D. INFLAMMATION E. COMPLEMENT SYSTEM F. OPSONIZATION G. CYTOKINES 1
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MAMMALIAN IMMUNE SYSTEM 2
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ACQUIRED AND SPECIFIC IMMUNITY (RESISTANCE) HUMORAL – ANTIBODIES (SOLUBLE, DIFFUSIBLE SPECIFIC) PROTEINS WHICH BIND CELLULAR INVADERS (BACTERIA) WHICH CAUSED THEIR SYNTHESIS AND STIMULATE PHAGOCYTOSIS AND BIND TOXINS AND VIRUSES WHICH CAUSED THEIR SYNTHESIS AND INACTIVATE THEM INFECTIOUS AGENTS ARE ANTIGENS – STIMULATE SPECIFIC ANTIBODY SYNTHESIS CELL – MEDIATED IMMUNITY - LYMPHOCYTES WHICH ATTACK HUMAN CELLS PRODUCING VIRUSES SPECIFICALLY AND KILL THEM TO LIMIT VIRUS INFECTION (AND OTHER CELLULAR INVADERS AND SOME CANCER CELLS); INFECTIOUS AGENTS ARE ANTIGENS – STIMULATE PRODUCTION OF SPECIFIC, IMMUNE LYMPHOCYTES
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INNATE RESISTANCE – BORN WITH IT – GENERAL RESISTANCE A. PHYSICAL (ANATOMICAL) BARRIERS 1. SKIN a. EPIDERMIS – OUTER LAYER KERATIN – INSOLUBLE PROTEINS –NAILS, HAIR, EPIDEMIS b. DERMIS – INNER LAYER – BOUND TO MUSCLE BY CONNECTIVE TISSUE 2. BLADDER - FLUSHING 3
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3. MUCOUS MEMBRANES – LINE RESPIRATORY, DIGESTIVE, UROGENITAL TRACTS; RESIST PENETRATION MUCUS – SECRETION – TRAPS MICROORGANISMS - CONTAINS LYSOZYME – HYDROLYZES PEPTIDOGLYCAN PATHOGENS WHICH COLONIZE MUCOUS MEMBRANES: NEISSERIA GONORRHOEAE MYCOBACTERIUM TUBERCULOSIS STRETOCOCCUS PYOGENES TREPONEMA PALLIDUM 4
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B. CHEMICAL BARRIERS 1. TEARS, SWEAT - LYSOZYME, [FLUSHING] 2. SALIVA - DIGESTIVE ENZYMES 3. INTERFERONS – ANTIVIRAL PROTEINS; CYTOKINES; INTER-CELLULAR SIGNALLING PROTEINS PRODUCED BY VIRUS-INFECTED CELLS BUT ACT ON UN-INFECTED CELLS TO LIMIT
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  • Fall '08
  • Whiteley

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