Type of Rxns and Requirements.pdf - SN2​​ Unimolecular...

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SN2 - - Unimolecular reaction (backside attack) - Inversion of Stereochemistry - Rate = Krxn [NU-][El+] - Good Nu- but poor bases (look at strength of conjugate acid)=SN2 only - , I , r , Cl N 3 B - Good Nu-, good base- = SN2 or E2 O , NH R R 3 - Look for ionic bases - Primary or secondary electrophile 2nd alkyl halide- with good Nu-(strong base), and poor ionizing solvent SN1 - - Formation of carbocation - Bimolecular reaction (formation of the cation) - Rate= Krxn [Nu-] - Weak/poor Nu- - Secondary and tertiary electrophile - 2nd alkyl halide with poor Nu-, polar ionizing solvent, substituents with resonance - Watch for cation rearrangements to form more stable cations in SN1 and E1 reactions E1- -Formation of carbocation Watch for cation rearrangements to form more stable cations in SN1 and E1 reactions -Conditions: heat Δ -major/minor product (major= most stable cation= most highly substituted: Zaitsev’s Rule) -weak/poor Nu- -secondary or tertiary Carbons E2- - Concerted reaction (happens at once) - Conditions: heat Δ - Good Nu-, good base- = SN2 or E2 O , NH
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