Biochemistry I Notes Post-midterm.pdf - BIOCHEMIST RY I CHEM 271 POST-MIDTERM Lecture 8 hmmmm Sucrose Glc sucrase ① Frc Lactose Gk Gal Endive(same m

Biochemistry I Notes Post-midterm.pdf - BIOCHEMIST RY I...

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Lecture 8 hmmmm sucrase Sucrose : Glc Frc Lactose : Gk Gal ( same onside ) TT ' " Endive :# e Maltose : Glc Gk m on same trick : all have Glucose side - - stores gk 9 kinase : adds Inline µ , @ phosphates -00ps Fructose phosphorylated w/ pros , a Fructo kinase : ATP ( phosphate donor ) on ,jg%fvo¥ aldolase " tpthosphorg *3BeasonsforPhosphoylation_ DHAP 1) no longer recognized by receptor G3P 2. Atp 2) Reduced ability to pass through becomes a invested hydrophobic membrane 3) ATP introduced into free molecule fat tissue fat tissue stored in adipose @ low glucose , - fructose comes 1hm Glc hexolhinase IOWEM - vs . fructose " Kim fructose hexokinase sina.IE?naTe i. binds than au Kin Inlier Lots of glucose , Low glucose levels , no competition
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Galactose Substrate for regime 's . . Galactose A f galactokinase + ATP Galactose - I - Phosphate B I' Eau 's : erase Glucose I - Phosphate Recall : glucose and galactose epimers C b phospho glucose isomerase Glucose - G Phosphate step l : 000 enzigalactokinase galactose - galactose t d phosphate phosphate released by Why ? charge -0 prevent hydrolysis of ATP transport through cell membrane - transporters don't recognize Minter mediate gym - s " Steph : galactose - glucose Inottheame : " my ex : galactose I - phosphate becomes a substrate Uridyl transferase alactoset - phosphate in separate / t UDP-glucose in - mde¥a¥@ End UDP galactose + glucose - I out out phosphate
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So far : UDP galactose 0 We now want : UDP-glucose V another - epimers @ Cy becomes a enz : UDP galactose -4 substrate joruidyl transferase epimerase substrate for / uridyl transferase galactose tp . " " " " " " " " " " " ÷÷÷ " " " " t " " " } - = suss€~ [email protected] Rrebdenmin the galactose I phosphate undid transferase enzyme rns autosomal recessive } unable to metabolize disease galactose t from enz . galactose t phosphate uridyl transferase em doesn't work : 9 galactose
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± .ee?H*otoEiiiis::Ii::iea : d galactose - galactitol t BAD ! ! in normal ppl , this is usually degraded Regulation defined by what its doing for you ! glucose - energy Http * Building blocks ; Good regulation sites :( 3 ring ) 3 types of ihegulalim ir rxns ! ! strive .us?8eori- Temporal Regulation : ggKdba( hormones travelling ex allosteric milliseconds Spatial Regulation thrush bloodstream phosphorylation seconds th !¥# fatfoeknigmelfector , hours - amount f- protein
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when 9ATP( LAMP ) last SHP mmmm igyonjs 's pyruvate kinase rxn won't go ¥ Atp allosteric ally inhibits pyruvate kinase intermediates .ae#modsaiie-Teegto:i::sjjifsYIIgp.a.eaftahi :aE :D " pyruvate kinase Atthestidownihegulate negotiating ¥¥sis¥e : see provide energy ! ! reeder : energy charge High Energy Charge -0 g y allosteric ally inhibits When Pftninhibilkdshexokinase also PFK Pyruvate kinase inhibited : upregulate moving Atyptalloskricakyaffipakssbstak L - PFK spied Feaf pyruvate : allosteric ally activated if rxn not fast enough , kinase by F- 1,6 - BP F - 1,6 BP accumulates El speeds up an
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