Bonten1992 - Originalia M B o n t e n E S t o b b e r i n g...

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Originalia M. Bonten, E. Stobberingh, J. Philips, A. Houben Antibiotic Resistance of Escherichia coil in Fecal Samples of Healthy People in Two Different Areas in an Industrialized Country* Summary: Fecal samples of 310 healthy persons, from two populations from different areas in the Netherlands, were examined for the presence of Escherichia coli resistant to ampicillin, tetracycline, sulfamethoxazole, trimethoprim and nitrofurantoin. High prevalences of resistance were found in both populations, ranging from 28% for trimethoprim to 89% for ampicillin. The percentages of the fecal samples with a dominantly resistant E. coli flora (> 50% resistance) were distinctly lower, ranging from 1% for nitrofurantoin to 21% for tetracycline. No significant differences in the level of resistance were observed between these two comparable populations in Zusammenfassung: Antibiotikaresistenz von Escherichia coli in Stuhlproben gesunder Personen in zwei ver- schiedenen Regionen eines Industrielandes. Escherichia coli-Resistenz gegen Ampicillin, Tetracyclin, Sulfa- methoxazol, Trimethoprim und Nitrofurantoin wurde in Isolaten aus Stuhlproben von 310 gesunden Personen aus zwei Bev61kerungsgruppen verschiedener Regionen der Niederlande gepriift. In beiden Populationen fanden sich hohe Resistenzraten von 28% gegen Trimethoprim bis 89% gegen Ampicillin. Der Prozentsatz von Stuhlproben mit dominant resistenter E. coli-Flora (mehr als 50% resistente St~imme) war eindeutig geringer mit 1% fiir Nitro- furantoin und 21 fiir Tetracyclin. Der Grad der Resistenz war zwischen den vergleichbaren Popu- two different areas. The susceptibilities to 11 antimicrobial agents of 456 at random isolated E. coli were determined. The percentages of resistance varied widely: from 80% for chloramphenicol to 9% for nitrofurantoin. Only 19% of the isolates were susceptible to all antibiotics tested and 14% were resistant to more than four of the agents tested. Great differences in resistance rates between the two populations examined were seen for chloramphenicol (80% to 41%) and trimethoprim (16% to 36%). The results of this study underscore the presence of a human reservoir of antibiotic resistant microorganisms. lationen dieser zwei verschiedenen Regionen nicht signifikant verschieden. Die Empfindlichkeit der von 456 Personen isolierten E. coli-Stftmmen gegen 11 Antibiotika wurde untersucht. Die Resistenzraten zeigten erhebliche Unterschiede von 80% ftir Chloramphenicol bis 9% fiJr Nitrofurantoin. Nur 19% der Isolate waren gegen alle Testantibiotika empfindlich, 14% waren gegen mehr als vier der Testsubstanzen resistent. Die beiden Populationen wiesen grol3e Unterschiede in den Resistenzraten gegen Chloramphenicol (80% gegenfiber 41%) und Trimethoprim (16% gegenfiber 36%) auf. Die Ergebnisse dieser Studie bestatigen das Vorliegen eines Reservoirs an resistenten Mikroorganismen beim Menschen.
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