WARFARIN DRUG INTERACTIONS1.pdf - WARFARIN DRUG INTERACTIONS1,2 The drugs in this list are more usually associated with loss of INR control in patients


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WARFARIN DRUG INTERACTIONS 1,2 The drugs in this list are more usually associated with loss of INR control in patients already established on warfarin. This list is not exhaustive - refer to the British National Formulary (BNF) for further information. If any of the drugs below are to be started in these patients then the use of alternatives in the same therapeutic class may be considered. If this is not possible then the patient’s INR should be monitored as detailed below. Those drugs highlighted in bold are significant interactions and should be avoided or used with caution. Drugs marked * are liver enzyme inhibitors and increase the INR. They act very quickly (can be within 24 hours) and if the drug is withdrawn the effect disappears quickly depending on the drug half-life. The INR should if possible be monitored within 72 hours of starting the interacting drug and on withdrawal. Drugs marked $ are liver enzyme inducers and decrease the INR. They act more slowly (up to
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