MCB130lectures1,2 - MCB 130 R Schekman Membrane Structure...

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MCB 130 Lectures 1, 2 R. Schekman Membrane Structure – Membrane Variety and Molecular Constituents A. Cells have membrane-bounded compartments 1. Membranes revealed by electron microscopy and by isolation of specialized organelles 2. Membranes provide for selective permeability of small molecules 3. Membranes perform mechanical functions in cell movement and division 4. Membranes serve in energy transduction 5. Membranes participate in intra- and intercellular communication B. The membrane matrix is formed by a lipid bilayer 1. Lipid components are amphipathic a. Phospholipid structure b. Sphingolipic structure c. Sterol structure 2. Stable higher-order structures formed by lipids a. Monolayers formed at an air water interface b. Micelles c. Biological membranes are composed predominantly of lipid bilayers 3. Fluidity of the bilayer dictated by lipids a. Influence of fatty acid chain length and degree of unsaturation b. Cells regulate membrane fluidity c. Influence of sterol on viscosity C. Most membrane related functions are performed by proteins 1. Membrane proteins may be considered in two categories
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