MCB130lectures8,9

MCB130lectures8,9 - but overlapping enzyme components....

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MCB130 Lectures 8, 9 R. Schekman Membrane Vesicular Traffic I. Transport from the endoplasmic reticulum A. Sorting of secretory and resident proteins 1. Proteins destined for transport are packaged into transport vesicles by coat proteins called COPII. 2. COPII assembly is spatially regulated by the ER location of a nucleotide exchange protein (GEF) that converts a specific GTP-binding protein, Sar1p, from Sar1-GDP Sar1-GTP. 3. Some resident proteins are transported and must be recycled back to the ER. This is achieved by another coat complex, COPI, and another GTP-binding protein and GEF. B. Traffic in the Golgi complex 1. The Golgi complex consists of a stack of membrane cisternae that have distinct
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Unformatted text preview: but overlapping enzyme components. Cisternae carry distinct glycosyl modifying enzymes. 2. Protein traffic within the Golgi progresses by a process of cisternal maturation very much like the assembly of an automobile on an assembly line. 3. Golgi membrane proteins within cisternae that mature are continuously recycled in COPI vesicles back to an earlier cisterna. 4. Proteins destined for secretion are packaged into several distinct carrier vesicles: a. Regulated granules carry hormones that are processed by special proteases. b. Vesicles transported constitutively to the cell surface and to specialized domains of the cell surface....
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MCB130lectures8,9 - but overlapping enzyme components....

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