Midterm1.130.05 - MCB130 Midterm 1 Fall `05 Signature SID...

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MCB130, Midterm 1 Fall ‘05 Name: Signature: SID: GSI: 1 Use only the space provided below to answer each question. Do not write on the back. For maximal credit, leave out extraneous information. 100 points total. 1. (10pts) How are sister chromatids held together in mitosis and how are chromosome homologs held together during meiosis I? 2. (12 pts) Provide three reasons why intermediate filaments can not exhibit treadmilling. 3. (16 pts) Briefly describe the function of each of the following skeletal muscle proteins. (a) The troponin complex (b) Tropomodulin (c) Nebulin (d) Titan
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MCB130, Midterm 1 Fall ‘05 Name: Signature: SID: GSI: 2 4. (15 pts) Motivated by the efficacy of taxol as a chemo-therapeutic agent for certain cancers, a biotechnology company decides to develop candidate drugs against non-tubulin microtubule-associated targets. Predict how a chemical inhibitor of each of the following targets might affect mitosis. Explain your answers. Refer to specific events in mitosis.
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