102 handout 1011 - Glucose 6-phosphate...

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Glucose 6-phosphate 6-phosphoglucono-δ-lactone 6-phosphogluconate G6P dehydrogenase 1 Lactonase 2 OH H 6-phosphogluconate dehydrogenase 3 NADP + NADPH + CO 2 Ribulose 5-phosphate Xylulose 5-phosphate Ribose 5-phosphate Sedoheptulose 7-phosphate GAP Erythrose 4-phosphate Fructose 6-phosphate GAP Fructose 6-phosphate Transaldolase 6 Transketolase 7 PENTOSE PHOSPHATE PATHWAY C-1 C-2 C-3 C-4 C-5 of ribulose 5-phosphate C-3 , C-4 , C-5 are in every sugar product C-1 is in every product except erythrose 4-phosphate and GAP C-2 is in every product except GAP Transketolase 5 Phosphopentose Epimerase 4a Phosphopentose Isomerase 4b NADP + NADPH H 2 O H +
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Metabolic Diseases-glycolysis, pentose phosphate pathway, glycogen breakdown and synthesis Pellagra- deficiency of niacin which is converted to nicotinamide (NAD), a coenzyme required for oxidative metabolic pathways like glycolysis. Symptoms- dermatitis, diarrhea and dementia Treatment- balanced diet (meat, milk, eggs), soaking of cornmeal in alkali Beriberi- deficiency of thiamine which is converted to thiamine pyrophosphate (TPP), a coenzyme required in the yeast
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