102 handout 1025 - MCB 102 Handout 10/25 FATTY ACID...

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MCB 102 Handout 10/25 FATTY ACID BREAKDOWN aka β OXIDATION Triacylglycerols are stored in adipocytes until a hormone-sensitive lipase hydrolyzes them to yield glycerol and three free fatty acids. STEP 1: Linkage to CoA STEP 2: Transport into the mitochondrion STEPS 3-6: β OXIDATION Fatty acid Fatty acyl-adenylate Fatty acyl-CoA Fatty acids are broken down 2 carbons at a time in a process called β oxidation because the β carbon is oxidized from a CH 2 to a C=O (carbonyl group) The process is illustrated for palmitate, a 16-carbon saturated fatty acid. It must be repeated 6 more times to completely degrade palmitate to acetyl-CoA.
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102 handout 1025 - MCB 102 Handout 10/25 FATTY ACID...

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